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What is Admelog® (insulin lispro injection) 100 Units/mL?
Prescription Admelog is a fast-acting human insulin used to improve blood sugar control in adults with Type 2 diabetes and adults and children (3 years and older) with Type 1 diabetes.
Important Safety Information
Do not use Admelog if you have low blood sugar or if you are allergic to insulin lispro or any of the other ingredients in Admelog.
Do not share needles, insulin pens, or syringes with others, even if the needle is changed. Do NOT reuse needles. You may give other people a serious infection, or get a serious infection from them.
Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred or damaged.
Before starting Admelog, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breastfeeding or planning to breastfeed.
Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Admelog. Your treatment with TZDs and Admelog may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms, including:
- Shortness of breath
- Sudden weight gain
- Swelling of your ankles or feet
Tell your doctor about all the medications you take, including OTC medicines, vitamins, supplements, and herbal supplements.
When used as a mealtime insulin, Admelog should be taken within 15 minutes before a meal or immediately after a meal. Test your blood sugar levels as directed by your doctor when using Admelog. Do not change your dose or type of insulin without talking to your doctor. Any change of insulin should be made cautiously and only under medical supervision.
Check your insulin label to verify that you have the correct insulin before each injection. Admelog must only be used if the solution is clear and colorless with no particles visible.
While using Admelog, do not drive or operate heavy machinery until you know how Admelog affects you. Do not drink alcohol or use medicines that contain alcohol.
Admelog may cause serious side effects that can lead to death, including:
- Low blood sugar (hypoglycemia). Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood changes, hunger.
- Serious allergic reactions. Get medical help right away if you have: a rash over your whole body, trouble breathing, fast heartbeat, feeling faint, or sweating.
- Low potassium in your blood (hypokalemia). Your doctor should monitor you for low blood potassium levels.
- Heart failure. Your doctor should monitor you closely while you are taking TZDs with Admelog.
Get emergency medical help if you have:
- Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.
Admelog may have additional side effects including injection site reactions which may include change in fat tissue, skin thickening, redness, swelling and itching.
Important Safety Information for Admelog® (insulin lispro injection) SoloStar®
Admelog SoloStar is a disposable single-patient-use prefilled insulin pen. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with the pen.
Important Safety Information for Admelog (insulin lispro injection) when used in a pump
Do not mix or dilute Admelog when used in a pump.
Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in the case of pump failure.
Click here for Full Prescribing Information for Admelog.
Click here for information on Sharps Medical Waste Disposal.
Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.
These are not all the possible side effects of Admelog. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610.
©2025. Sanofi. All rights reserved. Admelog is a registered trademark of Sanofi or an affiliate.
All registered trademarks cited are property of their respective owners.
The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
Indications and Usage for Apidra
Prescription Apidra is a fast (rapid) acting insulin used for adults and children with diabetes mellitus to control high blood sugar. It is not known if APIDRA is safe or effective in children less than 4 years of age with type 1 diabetes or in children with type 2 diabetes.
When used as a mealtime insulin, Apidra should be given within 15 minutes before or within 20 minutes after starting a meal.
Apidra may be infused subcutaneously by external insulin infusion pumps.
Important Safety Information
Do not use Apidra if you have low blood sugar reaction or if you are allergic to insulin glulisine or any of the ingredients in Apidra.
Do not share needles, insulin pens or syringes with others even if the needle is changed. Do NOT reuse needles. You may give other people a serious infection or get a serious infection from them.
Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting lipodystrophy (pitted or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred or damaged.
Before starting Apidra, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breastfeeding or planning to breastfeed.
Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Apidra. Your treatment with TZDs and Apidra may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have new or worsening symptoms, including:
- Shortness of breath
- Sudden weight gain
- Swelling of your ankles or feet
Tell your doctor about all medications you take, including OTC medicines, vitamins, supplements, and herbal supplements.
When used a mealtime insulin, Apidra should be taken within 15 minutes before a meal or within 20 minutes after starting a meal. Test your blood sugar levels as directed by your doctor when using Apidra. Do not change your dose or type of insulin without talking to your doctor. Any change of insulin should be made cautiously and only under medical supervision.
Check your insulin label to verify that you have the correct insulin before each injection. Use Apidra only if the solution is clear and colorless with no particles visible.
While using Apidra, do not drive or operate heavy machinery until you know how Apidra affects you. Do not drink alcohol or use medicines that contain alcohol.
Apidra may cause serious side effects that can lead to death, including:
- Low blood sugar (hypoglycemia). Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood changes, hunger.
- Serious allergic reactions. Get medical help right away if you have: a rash over your whole body, shortness of breath, trouble breathing, fast pulse, sweating or feeling faint
- Low potassium in your blood (hypokalemia). Your doctor should monitor you for low blood potassium levels.
- Heart failure. Your doctor should monitor you closely while you are taking TZDs with Apidra.
Get emergency medical help if you have:
- Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.
The most common side effects of APIDRA include: low blood sugar (hypoglycemia), weight gain, itching, rash, swelling, allergic reactions including injection site reactions, skin thickening or pits at the injection site (lipodystrophy).
Important Safety Information for Apidra® (insulin glulisine injection) SoloStar®
Apidra SoloSTAR is a disposable single-patient-use prefilled insulin pen. Please talk to your healthcare provider about proper injection techniques and follow instructions in the Instruction Leaflet that accompanies the pen.
Important Safety Information for Apidra® when used in a pump
Replace the infusion sets (reservoir, tubing, and catheter), and the Apidra in the reservoir at least every 48 hours and select a new infusion site. Do not mix or dilute Apidra when used in the pump. Failure of your insulin pump or infusion set or degradation of the insulin in the pump can cause hyperglycemia and ketoacidosis. Always carry an alternate form of insulin administration in the case of pump failure.
Click here for Full Prescribing Information for Apidra.
Click here for information on Sharps Medical Waste Disposal.
Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.
These are not all the possible side effects of Apidra. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610.
©2025. Sanofi. All rights reserved. Apidra is a registered trademark of Sanofi or an affiliate.
The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
What is Lantus® (insulin glargine injection) 100 Units/mL?
Prescription LANTUS is a long-acting man-made-insulin used to control high blood sugar in adults and children with diabetes mellitus.
- LANTUS is not for use to treat diabetic ketoacidosis
Important Safety Information
Do not take Lantus during episodes of low blood sugar or if you are allergic to insulin or any of the inactive ingredients in Lantus.
Do not share needles, insulin pens, or syringes with others. Do NOT reuse needles.
Before starting Lantus, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant or if you are breast-feeding or planning to breast-feed.
Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting lipodystrophy (pitted or thickened skin) and localized cutaneous amyloidosis (skin with lumps) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred or damaged.
Heart failure can occur if you are taking insulin together with certain medicines called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you already have heart failure, it may get worse while you take TZDs with Lantus. Your treatment with TZDs and Lantus may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms of heart failure, including:
- Shortness of breath
- Swelling of your ankles or feet
- Sudden weight gain
Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, including herbal supplements.
Lantus should be taken once a day at the same time every day. Test your blood sugar levels while using insulin, such as Lantus. Do not make any changes to your dose or type of insulin without talking to your healthcare provider. Any change of insulin should be made cautiously and only under medical supervision.
Do NOT dilute or mix Lantus with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Lantus must only be used if the solution is clear and colorless with no particles visible. Always make sure you have the correct insulin before each injection.
While using Lantus, do not drive or operate heavy machinery until you know how Lantus affects you. You should not drink alcohol or use other medicines that contain alcohol.
The most common side effect of insulin, including Lantus, is low blood sugar (hypoglycemia), which may be serious and life threatening. It may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision.
Lantus may cause serious side effects that can lead to death, such as severe allergic reactions. Get medical help right away if you have:
- A rash over your whole body
- Trouble breathing
- A fast heartbeat
- Sweating
- Swelling of your face, tongue, or throat
- Shortness of breath
- Extreme drowsiness, dizziness, or confusion
Other possible side effects may include swelling, weight gain, low potassium levels, injection site reactions, including changes in fat tissue at the injection site, and allergic reactions.
Important Safety Information for Lantus (insulin glargine injection) SoloStar
Lantus SoloSTAR is a disposable single-patient-use prefilled insulin pen. Please talk to your healthcare provider about proper injection technique and follow instructions in the Instruction Leaflet that accompanies the pen.
Click here for Full Prescribing Information for Lantus.
Click here for information on Sharps Medical Waste Disposal.
Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.
These are not all the possible side effects of Lantus. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610.
©2025. Sanofi. All rights reserved. Lantus is a registered trademark of Sanofi or an affiliate.
The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
What is Merilog™ (insulin aspart-szjj) injection 100 Units/mL?
MERILOG is a man-made insulin that is used to control high blood sugar in adults and children with diabetes mellitus.
Important Safety Information for MERILOG
What is the most important information I should know about MERILOG?
Do not share your MERILOG SoloStar® prefilled pen with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.
Who should not take MERILOG?
Do not take MERILOG if you:
- are having an episode of low blood sugar (hypoglycemia).
- have an allergy to insulin aspart products or any of the ingredients in MERILOG.
Before taking MERILOG, tell your healthcare provider about all your medical conditions including, if you are:
- pregnant, plan to become pregnant, or are breastfeeding.
- taking new prescription or over-the-counter medicines, vitamins, or herbal supplements.
Talk to your health care provider about low blood sugar and how to manage it.
How should I take MERILOG?
- Read the Instructions for Use and take exactly as directed.
- MERILOG starts acting fast. Eat a meal within 5 to 10 minutes after taking it.
- Know the type and strength of insulin you take. Do not change the type of insulin you take unless your healthcare provider tells you to. The amount of insulin and the best time for you to take your insulin may need to change if you take different types of insulin.
- Check your blood sugar levels. Ask your healthcare provider what your blood sugar levels should be and when you should check them.
- Do not reuse or share needles with other people. You may give other people a serious infection or get a serious infection from them.
- MERILOG can be injected under the skin (subcutaneously) of your stomach area (abdomen), buttocks, upper legs (thighs) or upper arms.
-
Change (rotate) your injection sites within the area you choose with each dose to reduce
your risk of getting pits in skin or thickened skin (lipodystrophy) and skin with lumps (localized
cutaneous amyloidosis) at the injection sites.
- Do not use the same exact spot for each injection.
- Do not inject where skin has pits, is thickened, or has lumps.
- Do not inject where skin is tender, bruised, scaly or hard, or into scars or damaged skin.
What should I avoid while taking MERILOG?
- Do not drive or operate heavy machinery, until you know how MERILOG affects you.
- Do not drink alcohol or use over-the-counter medicines that contain alcohol.
What are the possible side effects of MERILOG?
Serious side effects can lead to death, including:
Low blood sugar (hypoglycemia). Signs and symptoms that may indicate low blood sugar include:
- dizziness or lightheadedness
- sweating
- confusion
- blurred vision
- slurred speech
- shakiness
- fast heart beat
- anxiety, irritability, or mood changes
- hunger
- headache
Your insulin dose may need to change because of:
- change in level of physical activity or exercise
- weight gain or loss
- increased stress
- change in diet
- illness
Other common side effects of MERILOG may include:
- low potassium in your blood (hypokalemia), reactions at the injection site, itching, rash, serious allergic reactions (whole body reactions), skin thickening or pits at the injection site (lipodystrophy), weight gain, and swelling of your hands and feet.
Get emergency medical help if you have:
- Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, or confusion.
These are not all the possible side effects of MERILOG. Call your doctor for medical advice about side effects. You may report your side effects to FDA at 1-800-FDA-1088. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610.
Important Safety Information for MERILOG Solostar
MERILOG SoloStar is a disposable single-patient-use prefilled insulin pen. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with the pen.
Click here for full Prescribing information for MERILOG.
Click here for information on Sharps Medical Waste Disposal.
©2025 Sanofi. All rights reserved.
MERILOG, SoloStar, and Sanofi are registered trademarks of Sanofi or an affiliate.
The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
WHAT IS MULTAQ?
MULTAQ is a prescription medicine used to lower the chance of hospitalization for atrial fibrillation (AFib) in people who currently have a normal heart rhythm and have had certain types of AFib (paroxysmal or persistent AFib) in the past. It is not known if MULTAQ is safe and effective in children younger than age 18 years old.
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about MULTAQ?
MULTAQ may cause serious side effects, including:
Increased risk of death, stroke, and heart failure in people with:
- A certain type of heart failure called decompensated heart failure. Heart failure is when your heart does not pump blood through your body as well as it should. MULTAQ can cause new or worsening heart failure. Do not take MULTAQ if you have symptoms of heart failure that recently worsened and you were hospitalized, or if you have severe heart failure. Call your healthcare provider right away if you develop any of the following signs or symptoms of heart failure during treatment with MULTAQ: shortness of breath or wheezing at rest; wheezing, chest tightness, or coughing up frothy sputum at rest, nighttime, or after minor exercise; trouble sleeping or waking up at night because of breathing problems; using more pillows to prop yourself up at night so you can breathe more easily; gaining more than 5 pounds quickly; increasing swelling of feet or legs
- A certain type of irregular heartbeat (rhythm) called permanent atrial fibrillation (AFib). Permanent AFib is when you and your healthcare provider decide not to try to change your heart rhythm back to a normal heart rhythm or your heart rhythm cannot be changed back to a normal rhythm. Do not take MULTAQ if you have permanent AFib. Your healthcare provider should check your heart rhythm regularly to make sure your heart keeps a normal rhythm. Call your healthcare provider right away if you develop any of the following signs or symptoms of AFib during treatment with MULTAQ such as: fast or irregular heartbeat or pulse; chest pain; dizziness or lightheadedness; tiredness or weakness; reduced ability to exercise; shortness of breath
MULTAQ doubles your risk of dying if you have these conditions. Your healthcare provider may give you a medicine to help prevent blood clots and decrease your risk of stroke during treatment with MULTAQ. Tell your healthcare provider right away if you develop any of the following signs or symptoms of stroke during treatment with MULTAQ such as: numbness or weakness in the face, arms, or legs, especially on 1 side of the body; confusion, trouble speaking, or difficulty understanding things; trouble seeing in 1 or both eyes; trouble walking, dizziness, loss of balance, or lack of coordination.
- Liver problems. MULTAQ may cause severe liver problems, including life-threatening liver failure. Do not take MULTAQ if you have severe liver problems. Your healthcare provider may order blood tests to check your liver before you start taking MULTAQ and during treatment. Call your healthcare provider right away if you develop any of the following signs and symptoms of liver problems during treatment with MULTAQ: loss of appetite, nausea, vomiting; fever, feeling unwell, unusual tiredness; itching; yellowing of the skin or the whites of the eyes (jaundice); unusual darkening of the urine; right upper stomach area pain or discomfort
Who should not take MULTAQ?
See “What is the most important information I should know about taking MULTAQ?” Do not take MULTAQ if:
- you have a certain type of heart problem called heart block, and you do not have an implanted pacemaker
- your heart rate is less than 50 beats each minute
- you have had liver or lung problems after using amiodarone
- you have a certain type of electrocardiogram (ECG) abnormality including QTc or PR interval prolongation
- you take certain medicines that can change the amount of MULTAQ that gets into your body such as: nefazodone; ritonavir; ketoconazole; itraconazole; erythromycin; voriconazole; telithromycin; clarithromycin; cyclosporin
- you take certain medicines that can lead to a dangerous abnormal heart rhythm such as: phenothiazines; tricyclic antidepressants; macrolide antibiotics; certain medicines for abnormal heart rhythm or fast heartbeat (Class I and III antiarrhythmics)
- you are allergic to dronedarone or any of the other ingredients in MULTAQ
What should I tell my healthcare provider before taking MULTAQ?
Before taking MULTAQ, tell your healthcare provider about all of your medical conditions, including if you:
- have any other heart problems, including heart rhythm problems, or have had a stroke
- have an implanted pacemaker
- have liver or kidney problems
- have lung problems
- have low levels of potassium or magnesium in your blood
- are pregnant or plan to become pregnant. MULTAQ may harm your unborn baby Females who can become pregnant
- Your healthcare provider will do a pregnancy test before you start treatment with MULTAQ
- Use effective birth control (contraception) during treatment and for 5 days after your final dose of MULTAQ
- Tell your healthcare provider right away if you think you are pregnant or become pregnant during treatment with MULTAQ
- are breastfeeding or plan to breastfeed. It is not known if MULTAQ passes into your breast milk. Do not breastfeed during treatment and for 5 days after the final dose of MULTAQ
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking MULTAQ with certain other medicines may affect the amount of MULTAQ or other medicines in your blood and may increase your risk of side effects or affect how well MULTAQ or the other medicines work.
Especially tell your healthcare provider if you take: medicine for high blood pressure, chest pain, or other heart conditions; statin medicine to lower blood cholesterol; medicine for tuberculosis (TB); medicine for seizures; digoxin; warfarin or other blood thinner medicines; medicine for organ transplant; an herbal supplement called St. John’s wort; water pills (diuretics).
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.
What should I avoid while taking MULTAQ?
Do not drink grapefruit juice during treatment with MULTAQ. Grapefruit juice can increase the amount of MULTAQ in your blood and can increase your chance of getting side effects.
What are the possible side effects of MULTAQ?
Serious side effects can lead to death, including:
- See “What is the most important information I should know about MULTAQ?”
- Inflammation of the lungs, including scarring and thickening. Call your healthcare provider if you develop shortness of breath or a dry cough during treatment with MULTAQ
- Low potassium and magnesium levels in your blood. This can happen if you take certain water pills (diuretics) during treatment with MULTAQ. Your healthcare provider may check you for this problem before and during treatment. Tell your healthcare provider if you develop any of the following symptoms of low potassium or low magnesium during treatment with MULTAQ: nausea or vomiting; weakness or sleepiness; muscle weakness, spasms, or tremors; loss of appetite; constipation; heart palpitations; tingling or numbness
- Changes in the electrical activity in your heart called QT interval prolongation. QT interval prolongation can increase your chance of getting dangerous abnormal heart rhythms
- Kidney problems and kidney failure. MULTAQ can cause changes in kidney function that can be serious and lead to kidney failure, especially in people with heart failure or people with low body fluid levels. Your healthcare provider will check your blood for signs of kidney problems during treatment. Tell your healthcare provider if you develop any of the following symptoms of kidney problems during treatment with MULTAQ: loss of appetite; nausea and vomiting; muscle cramps; dry, itchy skin; swelling of the feet and ankles; shortness of breath; trouble sleeping; urinating too much or too little
The most common side effects of MULTAQ include: diarrhea; weakness, lack of energy, and feeling very tired or sleepy (asthenia); nausea; skin problems such as redness, rash, and itching; stomach area (abdominal) pain; slow heart rate (bradycardia); vomiting; indigestion.
Your healthcare provider may stop treatment with MULTAQ if you develop certain side effects. These are not all of the possible side effects of MULTAQ.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please click here for full Prescribing Information including Risk of SERIOUS SIDE EFFECTS.
Please click here for the MULTAQ Medication Guide (English).
If you are a patient experiencing problems with a Sanofi U.S. product, please contact Sanofi U.S. at 1-800-633-1610.
Click here to learn more about Sanofi’s commitment to fighting counterfeit drugs.
Sanofi does not provide medical advice, diagnosis, or treatment. The health information contained herein is provided for general educational purposes only. Your healthcare professional is the best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
SOLIQUA 100/33 is an injectable prescription medicine that contains 2 diabetes medicines, insulin glargine and lixisenatide, that is used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes.
- It is not recommended for people who also take lixisenatide or other medicines called glucagon- like peptide 1 (GLP-1) receptor agonist.
- It is not for use in people with diabetic ketoacidosis.
- It has not been studied in people who also take a short-acting (prandial) insulin.
- It is not known if SOLIQUA 100/33 is safe and effective in children.
Important Safety Information for SOLIQUA 100/33 (insulin glargine and lixisenatide) injection 100 Units/mL and 33 mcg/mL
What is the most important information I should know about SOLIQUA 100/33?
SOLIQUA 100/33 can cause serious side effects, including inflammation of the pancreas (pancreatitis).
Stop using SOLIQUA 100/33 and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.
Who should not use SOLIQUA 100/33?
Do not use SOLIQUA 100/33 if you:
- are having an episode of low blood sugar (hypoglycemia)
- have had a serious allergic reaction to insulin glargine, lixisenatide, or any of the ingredients in SOLIQUA 100/33. See “What are the possible side effects of SOLIQUA 100/33?” for symptoms of a serious allergic reaction.
Before using SOLIQUA 100/33, tell your healthcare provider about all your medical conditions, including if you:
- have or have had problems with your pancreas.
- have heart failure or other heart problems. If you have heart failure, it may get worse while you take thiazolidinediones (TZDs).
- have severe problems with your stomach, such as slowed emptying of your stomach or problems digesting food.
- are taking certain medicines called glucagon-like peptide 1 receptor agonists (GLP-1 receptor agonists).
- are scheduled to have surgery or other procedures that use general anesthesia or deep sleepiness (deep sedation).
- are pregnant or breastfeeding or plan to become pregnant or to breastfeed. It is not known if SOLIQUA 100/33 will harm your unborn baby or pass into your breast milk.
Tell your healthcare provider about all the medicines you take, including all prescription and over-the-counter medicines, vitamins, and herbal supplements. SOLIQUA 100/33 may affect the way some medicines work.
Before using SOLIQUA 100/33, talk to your healthcare provider about low blood sugar and how to manage it.
Especially tell your healthcare provider if you take:
- antibiotics or the pain reliever, acetaminophen. Take these medicines at least 1 hour before using SOLIQUA 100/33. If you must take these medicines, take them with a meal or a snack. You should not take these medicines at the same time that you take SOLIQUA 100/33.
- birth control pills that are taken by mouth (oral contraceptives). SOLIQUA 100/33 may lower the amount of the medicine in your blood from your birth control pills and they may not work as well to prevent pregnancy. Take your birth control pill at least 1 hour before your injection of SOLIQUA 100/33 or at least 11 hours after your SOLIQUA 100/33 injection.
How should I use SOLIQUA 100/33?
- Do not change your dose without first talking to your healthcare provider.
- Your healthcare provider should show you how to use SOLIQUA 100/33 before you use it for the first time
- Check the pen label each time you inject to make sure you are using the correct medicine.
- Do not take more than 60 units of SOLIQUA 100/33 each day. Do not take SOLIQUA 100/33 with other GLP-1 receptor agonists.
- Only use SOLIQUA 100/33 that is clear and colorless to almost colorless. If you see small particles, return it to your pharmacy for replacement.
- Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred or damaged.
- Do not remove SOLIQUA 100/33 from the pen with a syringe.
- Do not re-use or share needles with other people. You may give other people a serious infection, or get a serious infection from them.
- If you take too much SOLIQUA 100/33, call your healthcare provider or the Poison Help line at 1- 800-222-1222 or go to the nearest hospital emergency room right away.
- Check your blood sugar levels. Ask your healthcare provider what your blood sugar should be and when you should check.
What should I avoid while taking SOLIQUA 100/33?
While taking SOLIQUA 100/33 do not:
- Drive or operate heavy machinery, until you know how SOLIQUA 100/33 affects you.
- Drink alcohol or use prescription or over-the-counter medicines that contain alcohol.
What are the possible side effects of SOLIQUA 100/33?
SOLIQUA 100/33 can cause serious side effects including:
- See "What is the most important information I should know about SOLIQUA 100/33?"
-
Severe allergic reactions. Stop taking SOLIQUA 100/33 and get medical help right away if you have any symptoms of a severe allergic reaction including
- swelling of your face, lips, tongue or throat
- problems breathing or swallowing
- severe rash or itching
- fainting or feeling dizzy
- very rapid heartbeat
-
Low blood sugar (hypoglycemia). Your risk for getting low blood sugar is higher if you take another medicine that can cause low blood sugar.
Signs and symptoms of low blood sugar include:
- Dizziness or light-headedness
- sweating
- confusion or drowsiness
- headache
- blurred vision
- slurred speech
- shakiness
- fast heartbeat
- anxiety, irritability or mood changes
- hunger
- weakness
- feeling jittery
- Dehydration leading to Kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.
- Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use SOLIQUA 100/33. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
- Low potassium in your blood (hypokalemia).
- Heart failure. Taking certain diabetes pills called TZDs with SOLIQUA 100/33 may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with SOLIQUA 100/33. Your healthcare provider should monitor you closely while you are taking TZDs with SOLIQUA 100/33. Tell your healthcare provider if you have any new or worse symptoms of heart failure including shortness of breath, swelling of your ankles or feet, or sudden weight gain. Treatment with TZDs and SOLIQUA 100/33 may need to be adjusted or stopped by your healthcare provider if you have new or worse heart failure.
- Gallbladder problems. Gallbladder problems have happened in some people who take SOLIQUA 100/33. Tell your healthcare provider right away if you get symptoms of gallbladder problems which may include:
- pain in your upper stomach (abdomen)
- fever
- yellowing of skin or eyes (jaundice)
- clay-colored stools
- Food or liquid getting into the lungs during surgery or other procedures that use general anesthesia or deep sleepiness (deep sedation). SOLIQUA 100/33 may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking SOLIQUA 100/33 before you are scheduled to have a surgery or other procedures.
The most common side effects of SOLIQUA 100/33 include:
- low blood sugar (hypoglycemia)
- nausea
- stuffy or runny nose and sore throat
- diarrhea
- upper respiratory tract infection
- headache
Talk to your healthcare provider about any side effect that bothers you or does not go away.
These are not all the possible side effects of SOLIQUA 100/33. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610.
Click here for full Prescribing Information for SOLIQUA 100/33.
Click here for information on Sharps Medical Waste Disposal.
Click here to learn more about Sanofi’s commitment to fighting counterfeit drugs.
©2025. Sanofi. All rights reserved. Soliqua is a registered trademark of Sanofi or an affiliate.
The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
What is Toujeo U-300 (insulin glargine) injection 300 Units/mL?
Prescription Toujeo is a long-acting man-made insulin used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.
- Toujeo is not for the treatment of diabetic ketoacidosis
- It is not known if Toujeo is safe and effective in children under 6 years of age
Important Safety Information for Toujeo U-300 (insulin glargine) injection
Do not use Toujeo if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Toujeo.
Do not share your pen(s) with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
Before starting Toujeo, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.
Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.
Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Toujeo. Your treatment with TZDs and Toujeo may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:
- Shortness of breath
- Sudden weight gain
- Swelling of your ankles or feet
Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.
Toujeo should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection. Do NOT use a syringe to remove Toujeo from your pen. Your dose for Toujeo may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.
Do NOT dilute or mix Toujeo with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Use Toujeo only if the solution is clear and colorless with no particles visible.
While using Toujeo, do not drive or operate heavy machinery until you know how Toujeo affects you. Don’t drink alcohol or use other medicines that contain alcohol.
The most common side effect of Toujeo is low blood sugar (hypoglycemia), which may be serious and life-threatening. Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Toujeo may delay recovery from low blood sugar compared to shorter-acting insulins.
Toujeo may cause severe allergic reactions that can lead to death. Get medical help right away if you have:
- A rash over your whole body
- Shortness of breath
- Swelling of your face, tongue, or throat
- Extreme drowsiness, dizziness, or confusion
- Trouble breathing
- Fast heartbeat
- Sweating
Toujeo may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.
Toujeo SoloStar and Toujeo Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Toujeo SoloStar or Toujeo Max SoloStar pen.
Click here for full Prescribing Information for Toujeo U-300.
Click here for information on Sharps Medical Waste Disposal.
Click here to learn more about Sanofi’s commitment to fighting counterfeit drugs.
These are not all the possible side effects of Toujeo. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610.
©2025. Sanofi. All rights reserved. Toujeo is a registered trademark of Sanofi or an affiliate.
The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
What is Insulin Glargine U-300 injection?
Prescription Insulin Glargine U-300 is a long-acting man-made insulins used to control high blood sugar in adults and children who are 6 years of age and older with diabetes mellitus.
- Insulin Glargine U-300 is not for the treatment of diabetic ketoacidosis
- It is not known if Insulin Glargine U-300 is safe and effective in children under 6 years of age
Important Safety Information for Insulin Glargine U-300 injection
Do not use Insulin Glargine U-300 if you have low blood sugar or if you are allergic to insulin or any of the ingredients in Insulin Glargine U-300.
Do not share your pen(s) with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.
Before starting Insulin Glargine U-300, tell your doctor about all your medical conditions, including if you have liver or kidney problems, if you are pregnant or planning to become pregnant, or if you are breastfeeding or planning to breastfeed.
Change (rotate) your injection sites within the area you chose with each dose to reduce your risk of getting pitted or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites. Do not use the same spot for each injection or inject where the skin is pitted, thickened, lumpy, tender, bruised, scaly, hard, scarred, or damaged.
Heart failure can occur if you are taking insulin together with pills called TZDs (thiazolidinediones), even if you have never had heart failure or other heart problems. If you have heart failure, it may get worse while you take TZDs with Insulin Glargine U-300. Your treatment with TZDs and Insulin Glargine U-300, may need to be changed or stopped by your doctor if you have new or worsening heart failure. Tell your doctor if you have any new or worsening symptoms including:
- Shortness of breath
- Sudden weight gain
- Swelling of your ankles or feet
Tell your doctor about all the medications you take, including OTC medicines, vitamins, and supplements, and herbal supplements.
Insulin Glargine U-300 should be taken at the same time once a day. Test your blood sugar levels daily while using any insulin. Do not change your dose or type of insulin without talking to your doctor. Verify you have the correct insulin before each injection. Do NOT use a syringe to remove Insulin Glargine U-300 from your pen. Your dose for Insulin Glargine U-300 may be different from other insulins you have taken. Any change of insulin should be made cautiously and only under medical supervision.
Do NOT dilute or mix Insulin Glargine U-300 with any other insulin or solution. It will not work as intended and you may lose blood sugar control, which could be serious. Use Insulin Glargine U-300 only if the solution is clear and colorless with no particles visible.
While using Insulin Glargine U-300, do not drive or operate heavy machinery until you know how Insulin Glargine U-300 affects you. Don’t drink alcohol or use other medicines that contain alcohol.
The most common side effect of Insulin Glargine U-300 is low blood sugar (hypoglycemia), which may be serious and life-threatening. Severe hypoglycemia may cause harm to your heart or brain. Symptoms of serious low blood sugar may include shaking, sweating, fast heartbeat, and blurred vision. The long-acting effect of Insulin Glargine U-300 may delay recovery from low blood sugar compared to shorter-acting insulins.
Insulin Glargine U-300 may cause severe allergic reactions that can lead to death. Get medical help right away if you have:
- A rash over your whole body
- Shortness of breath
- Swelling of your face, tongue, or throat
- Extreme drowsiness, dizziness, or confusion
- Trouble breathing
- Fast heartbeat
- Sweating
Insulin Glargine U-300 may have additional side effects including swelling, weight gain, low potassium, and injection site reactions which may include change in fat tissue, skin thickening, redness, swelling, and itching.
Insulin Glargine U-300 SoloStar and Insulin Glargine U-300 Max SoloStar are single-patient-use prefilled insulin pens. It is important to perform a safety test when using a new pen for the first time. Talk to your doctor about proper injection technique and follow instructions in the Instruction Leaflet that comes with your Insulin Glargine U-300 SoloStar or Insulin Glargine U-300 Max SoloStar pen.
Click here for full Prescribing Information for Insulin Glargine U-300.
Click here for information on Sharps Medical Waste Disposal.
Click here to learn more about Sanofi’s commitment to fighting counterfeit drugs.
These are not all the possible side effects of Insulin Glargine U-300. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. If you are a patient experiencing problems with a Sanofi US product, please contact Sanofi US at 1-800-633-1610.
©2025. Sanofi. All rights reserved. Insulin Glargine U-300 is a registered trademark of Sanofi or an affiliate.
The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.
